Description

Black Lion Research Alpha Male Stack 2.0 (Follidrone 2.0, Viron, Letrone, Exotherm)

Black Lion Research Alpha Male Stack 2.0 (Follidrone 2.0, Viron, Letrone, Exotherm) Follidrone 2.0:

Epicatechin
Promotes AMPK
Increased Follistatin
Reduced myostatin
Reduded Activin A
Antioxidant

Ecklonia Cava: EC
Muscle mass
Fat loss
Promotes AMPK
Increased Follistatin
Reduced myostatin
Reduded Activin A
ACE inhibitor
Antioxidant
Vasodilator
Cardio protective
Increased brain function
Reduced cholesterol
GLUT4 Expression

Ecklonia Cava is one of the most well studied seaweeds on earth. Millions of dollars have been invested in the research of these ingredients. Its exceptional with regards to health benefits and safety. It is also exceptional with regards to its benefits to us as muscle gain and fat loss enthusiasts. Like Epicatechin, EC is a strong follistatin booster and as such myostatin inhibitor. In addition to its ability to reduce myostatin it is also a very solid ACE inhibitor. Ace inhibitors are interesting to say the very least. Ace inhibitors increase insulin sensitivity and glucose uptake into muscles. Lower ACE levels equates to lower overall bodyfat levels, increased fat metabolism in the liver, and the ability to process sugars much faster. In addition, increased cell surface GLUT4 increases nutrient shuttling into muscle tissue. It has been suggested that ACE inhibitor-induced positive effects may also be mediated by direct action on the skeletal muscle. In particular, two recently published observational studies documented that among hypertensive subjects free of CHF, treatment with ACE inhibitors was associated with better performance and muscular outcomes. Genetic studies also support the hypothesis that the ACE system may be involved in physical performance and skeletal muscle function. Effects on the skeletal muscle are probably mediated by mechanical, metabolic, anti-inflammatory, nutritional, neurological and angiogenetic actions. Individuals with the II genotype of the ACE gene have greater endurance and greater skeletal muscle trainability in some studies. Hypertensive patients taking ACE inhibitors have greater cross-sectional muscle mass and a slower decline in walking speed than those taking other antihypertensives in epidemiological studies. ACE inhibitors are also known to improve endothelial function, muscle glucose uptake, increase potassium levels, and modulate other hormonal systems including IGF-1, all of which could contribute to improved skeletal muscle function. Finally, ACE inhibitors could of course be mediating a direct effect on skeletal muscle structure and function; they are known to have trophic effects on myocardial tissue. Finally ACE inhibitors help us with fat loss independent of food intake. This appears to be due to a high energy expenditure related to increased metabolism of fatty acids in the liver, with the additional effect of increased glucose tolerance.

EC is a strong vasodilator and helps restore and increase endothelial function. EC can regenerate the vascular endothelium, the cells critical to the inner lining of the blood vessels. They generate the chemical nitric oxide (NO), which keeps the arterial walls to become relaxed and dilated. After a six-week study of EC, flow mediated dilation and NO mediated dilation increased by 60% and 50%. In another study, coronary artery disease patients were given EC for six weeks. Blood flow controlled by NO increased 50-60%. These results confirm that EC can rejuvenate damaged endothelial cells to produce NO. This effect was further confirmed in a study on erectile dysfunction (see below).

Scientists studied 31 men with erectile dysfunction (ED) for over six months. They compared eight weeks of EC use to Viagra. They looked at orgasmic function (OF), intercourse satisfaction (IS), overall satisfaction (OS), and erectile function (EF). Over those eight weeks, ECE scored 87%, 74%, 62%, and 66%. Viagra scored 27%, 44%, 39%, and 66%. No side effects were reported with EC:
DGAT Inhibition
Diacylglycerol acetyl transferase (DGAT) is the enzyme involved in the final step of triglyceride synthesis. Triglycerides are circulating fat bodies that ultimately wind up in the fat cells, and are almost always elevated in diabetes. They also have emerged as a major risk factor in vascular disease.
It was found that EC compounds inhibited DGAT more than 50%. In genetically caused obese laboratory rats, EC reduced body fat and increased physical activity. In another study, EC caused leanness and fat-resistance in animals given a high fat diet.

ECE Beverage: 2-Week Clinical Trial
In a human study, 141 young adults were given a beverage containing ECE at 200 mg daily. In two weeks their average weight dropped nearly 2.5 pounds, muscle mass increased by nearly 2.5 pounds, and body fat dropped by 4 pounds, or 7.48%. EC stimulates the body to burn fat by increasing muscle mass.
Flos carth
Increased Follistatin
Reduced myostatin
Reduded Activin A
antiinflammitory
antioxidant
Increased NO production

Flos Carthami extract was initially a target for me because of its ability to increase Follistatin (see Fig 1.). Increased Follistatin, decreased Myostatin and activin A lead to increased muscle building potential. Flos Carthami has a strong antioxidant effect and is highly anti inflammatory. more than one tester mentioned a reduction in overall muscular pain perception acutely post training and during the DOMS stage of recovery. Several studies indicate that FC improves endothelial function and NO production similar to EC and (-)-E extract.

ABSORPTION PACKAGE=

Quercetin/niacin co crystal
Vasodilator, Increased VO2 Max,
Absorption

Quercetin niacin co_crystals are a whole new ingredient. Everyone knows about quercetin and niacin but quercetin has very poor oral bioavailability and niacin causes severe flushing at decent doses. Bonding the molecules together increases the absorption of Quercetin many times over and prevents the Niacin flush. Quercetin has been mentioned for everything from endurance and an increase in VO2 Max to fat loss to its strong antioxidant effect, however, for our purpose we added it specifically for its ability to increase the absorption of our other ingredients. Specifically, epicatechin. Its as just an added bonus. Black Lion Research Alpha Male

Absorption=
Both of these tested exceptionally well and have strong scientific evidence supporting their use to increase the absporption of epicatechin.
Octyl gallate
Citrus bioflavaniods

REFS:
http://www.ncbi.nlm.nih.gov/pubmed/20385110
http://www.fiercebiotechresearch.com…oss/2008-04-29
http://www.pnas.org/content/early/20…90105.abstract
http://ageing.oxfordjournals.org/content/37/4/363.full
http://www.ncbi.nlm.nih.gov/pubmed/19026021
http://www.ncbi.nlm.nih.gov/pubmed/12398116
http://www.ncbi.nlm.nih.gov/pubmed/16787247

VIRON High grade Eurycoma longifolia (EL) extract plus Boron citrate. Raw plant material and extract have been used for centuries as a tonic for libido and sexual function. Studies indicate that it has tons of properties beneficial to the bodybuilder or weight trained athlete. Anyone who trains seriously knows what testosterone is and its vital importance to performance, strength and muscle gain not to mention libido and confidence and everything male. Lots of people don’t realize though that much of your Total testosterone is bound up and unusable. The majority of your test is bound to SHBG (Sex Hormone Binding Globulin). SHBG is a glycoprotein that binds to sex hormones, androgen and estrogen. Anything bound by SHBG is not available to bind to androgen receptors which is where we want it. EL raises testosterone levels, helps to manage estrogen, reduces cortisol and improves quality of life. Not all EL is equal though and we took great care to ensure we have the best possible extract that is only used by us. Many El products are fake, poor extracts or even just ground up plant material. Our EL is the highest possible quality and will always be the best EL available for any price. EL has been shown to have the following potential effects: Boosts testosterone Increases luteinizing hormone Promotes erection Reduces SHBG Increases Free testosterone Decreases cortisol Decreases estrogen Increased muscle mass Improved sexual performance EL is a star component to Viron but it’s not alone. We also include 10mg Boron citrate. Boron is a natural trace mineral that many people are deficient in. Boron has the potential to increase your FREE testosterone to levels high enough to create an abnormally anabolic environment. Even if your total testosterone levels are in normal ranges if your free test is very high it will be similar to total test being super high as its the free portion that really matters. BORON CITRATE PROPERTIES INCLUDE Increases Free testosterone Increased DHT Increased Vitamin D Decreases inflammation Increased muscle mass Improves joints Strengthens bones Reduces estrogen Lowers plasma lipid levels and enables removal of cholesterol through various means. Enhanced cognitive function. Hand eye coordination, Short term memory and concentration. Viron is a great supplement for: On natty supp cycles to keep test levels up and for the huge increase in free T. Also just for the added health benefits of both EL and Boron. Off cycle for increased test levels and to keep SHBG low. Lots of guys like to take EL year round for its mood and libido enhancing properties and many people are boron deficient. It is especially good for PCT. Post cycle your system is a mess. Furthermore you will benefit from the reduction in cortisol and general mood improvement everyone needs during PCT. Eurycoma Longifolia increases testosterone levels. Eurycoma Longifolia decreases Cortisol. EL Testosterone EL increases LH EL reduces estrogen. Black Lion Research Alpha Male

Letrone is a natural anabolic aromatase inhibitor. Atractylodes Macrocephala- Atractylodes macrocephala Koidz (A. macrocephala), a Chinese medicinal herb, has been extensively used to treat digestive diseases in China and most other Asian countries (PPRC, 2005; Lee et al, 2007). Dry rhizomes of A. macrocephala are rich in sesquiterpenes and acetylenic compounds (Endo et al, 1979; Chen 1987; Huang et al, 1992; Lin et al, 1997). Typical polysaccharides atractan A, B, and C, present in A. macrocephala, have been reported to exhibit hypoglycaemic activities (Wang et al, 2000; Jia et al, 2003). Although atractylenolide I, atractylenolide II and atractylenolide III are all bioactive substances present in Atractylodes macrocephalae, the majority of research studies carried out in the recent years have focused on atractylenolide II and atractylenolide III (Kang et al., 2011b). Atractylenolide II is a marker substance present in Atractylodes macrocephalae which exhibits well-documented gastrointestinal inhibitory effects and anticancer activity (Zhang et al., 1999; Liu et al., 2005). Atractylenolide II is one of the main constituents present in the effective volatile oil fraction (Li et al., 2001), potentially effective in treating senile dementia. Atractylenolide III is a possible candidate for the treatment of human lung carcinoma (Kang et al., 2011a).Aromatase inhibition Primary targets for aromatase inhibition are atractylenolide 1 2 and 3 with atractylenolide 1 being exceptionally strong with 94.5% inhibition. Abstract:Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future. =http://www.jourlib.org/paper/162974#.VYtA8UYqPaoAtractylenolides are exceptionally strong aromatase inhibitors that show exceptional oral bioavailability. There are many AIs in nature. During my research I must have found over 100 potentials but unfortunately 99.9999% of them are poorly absorbed orally which limits their potential. Atractylenolide in contrast is  very well absorbed. Sites- -“Atractylenolide I is absorbed quite well at all segments of intestine in rats and no specific absorption was founded in different segment.” -“Atractylenolide I can be classified into high penetrating drug. Passive diffusion dominates the absorptive transport behivior of atractylenolide I. Atractylenolide I can be absorbed in the whole intestinal segments and there is not a preferntial absorption zone in the intestine. The absorption and secretion of atractylenolide I are mediated by the efflux transport system, P-gp.” -“Abstract The intestinal permeability of three sesquiterpene lactones, atractylenolide I, II, and III, was investigated using the human Caco-2 cell monolayer model. The bidirectional permeability of the three compounds from the apical (AP) to the basolateral (BL) side and in the reserved direction was studied. The three compounds were assayed using HPLC. The P app values of atractylenolide I, II, and III were all at the level of 10 -5 cm / s, suggesting high intestinal permeability and good absorption. The bidirectional transport of the three compounds was time- and concentration-dependent, and indicated the main mechanism of the passive diffusion of the three compounds across the intestinal epithelium membrane. Moreover, atractylenolide I might be partly actively transported. “[/I] ANABOLIC- It was a huge loss when Formeron got canned because well….Ais are great but formestane was also anabolic. Letrone is a stout AI but it also shows significant anabolic potential by increasing endogenous hormones. In one animal study growth was increased by 20% compared to control when animals were fed polysaccharides of atractylodes macrocephala. The increase in growth was attributed to increases in- Growth hormone x30% IGF-1 x52% T3 x47% T4 x36% cAMP x21% Sites- http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWXK201003005.htm “Comparing to the control group,the PAM group increased the average gain weight by 20.72%” “increased the levels of growth hormone(GH),insulin-like growth factor-I(IGF-I),3,5,3′-triiodothyronine(T3),3,5,3′,5′-tetraiodothyronine(T4) and cyclic adenosine monophosphate(cAMP) in serum by 30.77%(P0.05),52.02%(P0.05),47.60%(P0.05),36.70%(P0.05) and 21.15%(P0.05),respectively.The results indicated that PAM improved the growth performance of weaned piglets through the endocrinal system.Furthermore,it is possible that PAM altered the growth performance of weaned piglets by up-regulating the synthesis and secretion of GH,IGF-1,T3,T4 and cAMP.” Finally, Atractylodes macrocephala potentiates Ghrelin secretion and receptor signaling. Ghrelin increases hunger and Growth hormone secretion. Now you have not only an exceptionally strong oral AI but one that has serious anabolic potential.