Description
Black Lion Research Follidrone 2.0/Letrone/Prolactrone
Black Lion Research Follidrone 2.0/Letrone/Prolactrone This stack should promote increased mood and sense of well being from optimized hormonal production, lowering prolactin while boosting testosterone and controlling estrogen.
Black Lion Research Follidrone 2.0/Letrone/Prolactrone is proud to announce the release of Letrone. This product is a natural anabolic aromatase inhibitor. Atractylodes Macrocephala- Atractylodes macrocephala Koidz (A. macrocephala), a Chinese medicinal herb, has been extensively used to treat digestive diseases in China and most other Asian countries (PPRC, 2005; Lee et al, 2007). Dry rhizomes of A. macrocephala are rich in sesquiterpenes and acetylenic compounds (Endo et al, 1979; Chen 1987; Huang et al, 1992; Lin et al, 1997). Typical polysaccharides atractan A, B, and C, present in A. macrocephala, have been reported to exhibit hypoglycaemic activities (Wang et al, 2000; Jia et al, 2003). Although atractylenolide I, atractylenolide II and atractylenolide III are all bioactive substances present in Atractylodes macrocephalae, the majority of research studies carried out in the recent years have focused on atractylenolide II and atractylenolide III (Kang et al., 2011b). Atractylenolide II is a marker substance present in Atractylodes macrocephalae which exhibits well-documented gastrointestinal inhibitory effects and anticancer activity (Zhang et al., 1999; Liu et al., 2005). Atractylenolide II is one of the main constituents present in the effective volatile oil fraction (Li et al., 2001), potentially effective in treating senile dementia. Atractylenolide III is a possible candidate for the treatment of human lung carcinoma (Kang et al., 2011a). Aromatase inhibition Primary targets for aromatase inhibition are atractylenolide 1 2 and 3 with atractylenolide 1 being exceptionally strong with 94.5% inhibition. Abstract:Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future. = http://www.jourlib.org/paper/162974#.VYtA8UYqPao Atractylenolides are exceptionally strong aromatase inhibitors that show exceptional oral bioavailability. There are many AIs in nature. During my research I must have found over 100 potentials but unfortunately 99.9999% of them are poorly absorbed orally which limits their potential. Atractylenolide in contrast is very well absorbed. Sites- -“Atractylenolide I is absorbed quite well at all segments of intestine in rats and no specific absorption was founded in different segment.” -“Atractylenolide I can be classified into high penetrating drug. Passive diffusion dominates the absorptive transport behivior of atractylenolide I. Atractylenolide I can be absorbed in the whole intestinal segments and there is not a preferntial absorption zone in the intestine. The absorption and secretion of atractylenolide I are mediated by the efflux transport system, P-gp.” -“Abstract The intestinal permeability of three sesquiterpene lactones, atractylenolide I, II, and III, was investigated using the human Caco-2 cell monolayer model. The bidirectional permeability of the three compounds from the apical (AP) to the basolateral (BL) side and in the reserved direction was studied. The three compounds were assayed using HPLC. The P app values of atractylenolide I, II, and III were all at the level of 10 -5 cm / s, suggesting high intestinal permeability and good absorption. The bidirectional transport of the three compounds was time- and concentration-dependent, and indicated the main mechanism of the passive diffusion of the three compounds across the intestinal epithelium membrane. Moreover, atractylenolide I might be partly actively transported. “[/I] ANABOLIC- It was a huge loss when Formeron got canned because well….Ais are great but formestane was also anabolic. Letrone is a stout AI but it also shows significant anabolic potential by increasing endogenous hormones. In one animal study growth was increased by 20% compared to control when animals were fed polysaccharides of atractylodes macrocephala. The increase in growth was attributed to increases in- Growth hormone x30% IGF-1 x52% T3 x47% T4 x36% cAMP x21% Sites- http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWXK201003005.htm “Comparing to the control group,the PAM group increased the average gain weight by 20.72%” “increased the levels of growth hormone(GH),insulin-like growth factor-I(IGF-I),3,5,3′-triiodothyronine(T3),3,5,3′,5′-tetraiodothyronine(T4) and cyclic adenosine monophosphate(cAMP) in serum by 30.77%(P0.05),52.02%(P0.05),47.60%(P0.05),36.70%(P0.05) and 21.15%(P0.05),respectively.The results indicated that PAM improved the growth performance of weaned piglets through the endocrinal system.Furthermore,it is possible that PAM altered the growth performance of weaned piglets by up-regulating the synthesis and secretion of GH,IGF-1,T3,T4 and cAMP.” Finally, Atractylodes macrocephala potentiates Ghrelin secretion and receptor signaling. Ghrelin increases hunger and Growth hormone secretion. Now you have not only an exceptionally strong oral AI but one that has serious anabolic potential.
Black Lion Research Prolactrone
Increases dopamine levels Increases HGH levels up to 600% or more! Improves mood Improves sleep Increases libido Can reduce cholesterol Increase energy Increase fat burning Reduces bodyfat, increase muscle mass, better sleep and improvements in skins texture
YOU SHOULD NOT USE PROLACTRONE WITH: MAOIs (Nonspecific monoamine-oxidase inhibitors), powerful antidepressant drugs Antipsychotic drugs, such as phenothiazines, butyrophenones and reserpine Antihypertensive drugs such as guanethidine and methyldopa (may cause increased hypotension) Use Prolactrone cautiously with dopaminergic drugs such as amantadine, benserazide, carbidopa, atropine, and amphetamine, only under the guidance of a trained health care professional. Do not take if you have any pre existing medical issues. Consult a Doctor before beginning any dietary supplement.
Epicatechin
Promotes AMPK
Increased Follistatin
Reduced myostatin
Reduded Activin A
Antioxidant
Ecklonia Cava: EC
Muscle mass
Fat loss
Promotes AMPK
Increased Follistatin
Reduced myostatin
Reduded Activin A
ACE inhibitor
Antioxidant
Vasodilator
Cardio protective
Increased brain function
Reduced cholesterol
GLUT4 Expression
Ecklonia Cava is one of the most well studied seaweeds on earth. Millions of dollars have been invested in the research of these ingredients. Its exceptional with regards to health benefits and safety. It is also exceptional with regards to its benefits to us as muscle gain and fat loss enthusiasts. Like Epicatechin, EC is a strong follistatin booster and as such myostatin inhibitor. In addition to its ability to reduce myostatin it is also a very solid ACE inhibitor. Ace inhibitors are interesting to say the very least. Ace inhibitors increase insulin sensitivity and glucose uptake into muscles. Lower ACE levels equates to lower overall bodyfat levels, increased fat metabolism in the liver, and the ability to process sugars much faster. In addition, increased cell surface GLUT4 increases nutrient shuttling into muscle tissue. It has been suggested that ACE inhibitor-induced positive effects may also be mediated by direct action on the skeletal muscle. In particular, two recently published observational studies documented that among hypertensive subjects free of CHF, treatment with ACE inhibitors was associated with better performance and muscular outcomes. Genetic studies also support the hypothesis that the ACE system may be involved in physical performance and skeletal muscle function. Effects on the skeletal muscle are probably mediated by mechanical, metabolic, anti-inflammatory, nutritional, neurological and angiogenetic actions. Individuals with the II genotype of the ACE gene have greater endurance and greater skeletal muscle trainability in some studies. Hypertensive patients taking ACE inhibitors have greater cross-sectional muscle mass and a slower decline in walking speed than those taking other antihypertensives in epidemiological studies. ACE inhibitors are also known to improve endothelial function, muscle glucose uptake, increase potassium levels, and modulate other hormonal systems including IGF-1, all of which could contribute to improved skeletal muscle function. Finally, ACE inhibitors could of course be mediating a direct effect on skeletal muscle structure and function; they are known to have trophic effects on myocardial tissue. Finally ACE inhibitors help us with fat loss independent of food intake. This appears to be due to a high energy expenditure related to increased metabolism of fatty acids in the liver, with the additional effect of increased glucose tolerance.
EC is a strong vasodilator and helps restore and increase endothelial function. EC can regenerate the vascular endothelium, the cells critical to the inner lining of the blood vessels. They generate the chemical nitric oxide (NO), which keeps the arterial walls to become relaxed and dilated. After a six-week study of EC, flow mediated dilation and NO mediated dilation increased by 60% and 50%. In another study, coronary artery disease patients were given EC for six weeks. Blood flow controlled by NO increased 50-60%. These results confirm that EC can rejuvenate damaged endothelial cells to produce NO. This effect was further confirmed in a study on erectile dysfunction (see below).
Scientists studied 31 men with erectile dysfunction (ED) for over six months. They compared eight weeks of EC use to Viagra. They looked at orgasmic function (OF), intercourse satisfaction (IS), overall satisfaction (OS), and erectile function (EF). Over those eight weeks, ECE scored 87%, 74%, 62%, and 66%. Viagra scored 27%, 44%, 39%, and 66%. No side effects were reported with EC:
DGAT Inhibition
Diacylglycerol acetyl transferase (DGAT) is the enzyme involved in the final step of triglyceride synthesis. Triglycerides are circulating fat bodies that ultimately wind up in the fat cells, and are almost always elevated in diabetes. They also have emerged as a major risk factor in vascular disease.
It was found that EC compounds inhibited DGAT more than 50%. In genetically caused obese laboratory rats, EC reduced body fat and increased physical activity. In another study, EC caused leanness and fat-resistance in animals given a high fat diet.
ECE Beverage: 2-Week Clinical Trial Black Lion Research Follidrone 2.0/Letrone/Prolactrone
In a human study, 141 young adults were given a beverage containing ECE at 200 mg daily. In two weeks their average weight dropped nearly 2.5 pounds, muscle mass increased by nearly 2.5 pounds, and body fat dropped by 4 pounds, or 7.48%. EC stimulates the body to burn fat by increasing muscle mass.
Flos carth
Increased Follistatin
Reduced myostatin
Reduded Activin A
antiinflammitory
antioxidant
Increased NO production
Flos Carthami extract was initially a target for me because of its ability to increase Follistatin (see Fig 1.). Increased Follistatin, decreased Myostatin and activin A lead to increased muscle building potential. Flos Carthami has a strong antioxidant effect and is highly anti inflammatory. more than one tester mentioned a reduction in overall muscular pain perception acutely post training and during the DOMS stage of recovery. Several studies indicate that FC improves endothelial function and NO production similar to EC and (-)-E extract.
ABSORPTION PACKAGE= Black Lion Research Follidrone 2.0/Letrone/Prolactrone
Quercetin/niacin co crystal
Vasodilator, Increased VO2 Max,
Absorption
Quercetin niacin co_crystals are a whole new ingredient. Everyone knows about quercetin and niacin but quercetin has very poor oral bioavailability and niacin causes severe flushing at decent doses. Bonding the molecules together increases the absorption of Quercetin many times over and prevents the Niacin flush. Quercetin has been mentioned for everything from endurance and an increase in VO2 Max to fat loss to its strong antioxidant effect, however, for our purpose we added it specifically for its ability to increase the absorption of our other ingredients. Specifically, epicatechin. Its as just an added bonus.
Absorption=
Both of these tested exceptionally well and have strong scientific evidence supporting their use to increase the absporption of epicatechin.
Octyl gallate
Citrus bioflavaniods
Reviews
There are no reviews yet.